Masterclass in Cardiac Amyloidosis: Disease Spectrum, Diagnosis and Management

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Join us March 7-9, 2025, for the virtual Masterclass in Cardiac Amyloidosis: Disease Spectrum, Diagnosis and Management.

Led by Program Chair, Saurabh Malhotra, MD, MPH, FASNC, Masterclass features multidisciplinary content that today’s practitioners need to keep current in the rapidly advancing field of cardiac amyloidosis.

Masterclass will cover:

• the pathogenesis of cardiac amyloidosis;
• diagnostic techniques and pitfalls;
• management strategies;
• mechanisms to facilitate early diagnosis; and
• treatment and management.

The program will feature in-depth sessions led by expert cardiologists, multimodality imagers, hematologists, and neurologists to discuss the disease spectrum, diagnosis, and management of cardiac amyloidosis.

For Technologists: There will be a two-hour session, “Amyloidosis for Technologists: Tips and Tricks from Experts” on Saturday, March 8 from 1-3pm ET.

This session is essential for technologists who are or will be performing radionuclide imaging for cardiac amyloidosis. Leading experts will guide you through an overview of the disease, image acquisition and processing and recommendations to avoid potential pitfalls.

This program is offered free of charge.

Credits

Earn up to 10 CME/MOC credits.
2 CE credits for the technologist session, Amyloidosis for Technologists: Tips and Tricks from Experts.

Learning Objectives

By the end of the program, you should be able to:

• Describe amyloidosis, including specific types, cardiac features, and disease burden.
• Identify barriers to identification and diagnosis of patients suspected of ATTR.
• Summarize the diagnostic evaluation for cardiac amyloidosis including multimodality imaging and laboratory testing and identify prognostic markers.
• Recognize patients at risk for hereditary ATTR (hATTR) and wild-type ATTR (wtATTR).
• Explain the importance of genetic testing in hATTR.
• Discuss the therapeutic landscape and impact on disease burden.
• Define appropriate treatment and management strategies for patients with heart failure.
• Formulate strategies for development of a multidisciplinary care team.
• Evaluate potential community outreach activities to identify at-risk patients.

Program Chair

Saurabh Malhotra, MD, MPH, FASNC

Watch the Agenda Preview

Agenda

Friday, March 7, 2025

5:00 pm – Introduction, Program Goals and Logistics
Faculty: Saurabh Malhotra, MD, MPH, FASNC

5:05 pm – #1. ASNC’s role in amyloidosis education
Faculty: Panithaya Chareonthaitawee, MD

Session 1: Disease and Pathogenesis: Moderator – Saurabh Malhotra, MD, MPH, FASNC
5:10 pm – #2. Amyloid fibrils and amyloidogenesis
Faculty: Jonathan Wall, PhD

5:40 pm – #3. Clinical manifestations of amyloidosis: moving the needle to early diagnosis
Faculty: Frederick Ruberg, MD

6:10 pm – #4. Polyneuropathy for the non-neurologists
Faculty: Tawfiq Al-lahham, MD

6:40 pm – #5. Need for increasing awareness of musculoskeletal manifestations of amyloidosis
Faculty: Mazen Hanna, MD

7:10 pm – Summary and closing comments
Faculty: Saurabh Malhotra, MD, MPH, FASNC

Saturday, March 8, 2025

10:00 am – Introduction to Day 2
Faculty: Saurabh Malhotra, MD, MPH, FASNC

Session 2: Diagnostic Techniques and Pitfalls: A Case-Based Discussion: Moderator – Prem Soman, MD, PhD, MASNC
10:05 am – #6. Routine and advanced echocardiography techniques
Faculty: Matthew Parker, MD

10:35 am – #7. Cardiac magnetic resonance for diagnosis and disease management
Faculty: Sarah Cuddy, MD, FASNC

11:05 am – #8. Nuclear scintigraphy with bone avid tracers: Basics and beyond
Faculty: Saurabh Malhotra, MD, MPH, FASNC

11:35 am – #9. Amyloid mutations and role of genetic testing
Faculty: Ashutosh Wechalekar, MBBS, MD

12:05 pm – #10. Role of tissue diagnosis and challenges
Faculty: Angela Dispenzieri, MD

12:35 pm – Final comments
All faculty

12:35 pm – Break

Session 3: Challenges in Diagnosis and Management of ATTR: Moderator – Frederick Ruberg, MD
1:00 pm – #11. Amyloidosis in the community
Faculty: Isabelle Lousada and Foluso Fakorede, MD

1:45 pm – #12. Challenges with access to treatment
Faculty: Mathew Maurer, MD

2:15 pm – #13. Challenges in underrepresented populations (age, ethnicity)
Faculty: Kevin Alexander, MD

2:45 pm – Panel discussion: Everyday challenges
All faculty

3:15 pm – Closing comments

Sunday, March 9, 2025

10:00 am – Introduction to Day 3
Faculty: Saurabh Malhotra, MD, MPH, FASNC

Session 4: Practical Concepts for Treatment of Amyloidosis: Moderator – Saurabh Malhotra, MD, MPH, FASNC
10:05 am – #14. Application of prognostic markers in AL and ATTR amyloidosis
Faculty: Andrew Staron, MD

10:30 am – #15. Differentiating TTR from myeloma precursors
Faculty: Anita D’Souza, MD

11:00 am – #16. How to determine choice of therapy: Is more better?
Faculty: Prem Soman, MD, PhD, MASNC

11:30 am – #17. Management of HF in amyloid patients
Faculty: Ahmad Masri, MD

12:00 pm – Q&A
All faculty

12:30 pm – Final comments and adjourn
Faculty: Saurabh Malhotra, MD, MPH, FASNC

*Credits subject to change

Amyloidosis for Technologists: Tips and Tricks from Experts

Overview

As part of this year’s Amyloidosis Masterclass (March 7-9 , 2025) ASNC will offer a focused 2-hour session for technologists titled, Amyloidosis for Technologists: Tips and Tricks from Experts on Saturday, March 8 from 1-3pm ET. This session is essential for technologists who are or will be performing radionuclide imaging for cardiac amyloidosis. This session will provide an overview of the disease, image acquisition and processing and recommendations to avoid potential pitfalls. Join us for an informative session with leading experts. The session will offer 2* CE credits for technologists.

Objectives

• Describe the importance of differentiating amyloid transthyretin cardiac amyloidosis from light-chain amyloidosis
• Compare technetium-99m (Tc-99m) HMDP and Tc-99m PYP for diagnosis of cardiac amyloidosis
• Summarize key parameters acquisition and processing of Tc-99m bone avid tracers with NaI and CZT camera systems.
• Identify artifacts and common pitfalls associated with Tc-99m bone avid tracers for detecting cardiac amyloidosis

Agenda

Saturday, March 8, 2025, 1:00 pm – 3:00 pm (US ET)

1:00 pm – Welcome and Logistics
1:05 pm – Overview of cardiac amyloidosis
1:30 pm – Radionuclide image acquisition and processing for ATTR cardiac amyloidosis on NaI systems
2:00 pm – Radionuclide image acquisition and processing for ATTR cardiac amyloidosis on CZT systems
2:30 pm – Artifacts and pitfalls, and how to avoid them?
3:00 pm – Final questions

Faculty

This program is supported by an unrestricted educational grant from BridgeBio.