Cardiac Amyloidosis

Cardiac Amyloidosis
ASNC is the premier source for education and quality in the rapidly expanding area of cardiac amyloidosis. Through its initiatives and partnerships, ASNC is supporting a collaborative approach to awareness, early diagnosis and effective treatments that will save lives and improve quality of life for patients with CA. As the medical society focused on nuclear cardiology, ASNC is uniquely qualified to provide education, information and advocacy that ensures appropriate referrals for Tc-99m PYP imaging; supports high-quality testing, interpretation and reporting of Tc-99m PYP imaging by imagers; and encourages fair reimbursement of Tc-99m PYP services and approval of CA treatment agents.


Advances in Cardiac Amyloidosis  Date: Wednesday, October 9, 2019
Time:  11:59 PM - 1:00 AM (US  Eastern Time)                                                                                                                                                           
Moderators: Dr. Diana Paez and Dr. Prem Soman
  • Diagnosis of Cardiac Amyloidosis: ASNC/Multisocietal Consensus Recommendations: Sharmila Dorbala, MD, FASNC
  • 99mTc-Bone Tracer Imaging for ATTR Cardiac Amyloidosis: Professor, dr. Riemer Slart, MD, PhD
  • Novel Treatments for ATTR Cardiac Amyloidosis: Professer Claudio Rapezzi, MD
  • Discussion: Dr. Prem Soman
Sharmila Dorbala, MD, MPH, FASNC, Prem Soman, MD, PhD, MASNC, Diana Paez, MD, Professor Claudio Rapezzi, MD, Professor,dr. R.H.J.A. (Riemer) Slart
No CME or CE credit is provided.



Clinical Application of Tc-99m PYP Imaging in Suspected Cardiac Amyloidosis

Date: Thursday, September 26, 2019
Time: 2 pm ET (1 hour)
Faculty: Jamieson M. Bourque, MD, MHS and Sabahat Bokhari, MD, Presenters
CME/CE credit is not available for this activity
Fee: ASNC Members, free; Non-members, $25
This activity is sponsored by Pfizer.
Archive link coming soon!

CME Webinar Series: Lessons in Transthyretin Cardiac Amyloidosis

Cardiac Amyloidosis Treatments Today, Emerging Treatments for Tomorrow
Aired: May 2019
Faculty: Sharmila Dorbala, MD, MPH, FASNC, Chair, and Prem Soman, MD, MASNC, Co-moderators. Rodney Falk, MD and Mathew Maurer, MD, Presenters
Credit: AMA PRA Category 1 CreditsTM (CME) for Physicians
Fee: ASNC Members, free; Non-members, $75
This activity is supported by an educational grant from Pfizer.

State of the Art Imaging in Cardiac Amyloidosis
Aired: March 2019
Faculty: Sharmila Dorbala, MD, MPH, FASNC, Chair, and Jamieson Bourque, MD, Co-moderators. Frederick Ruberg, MD and Wael Jaber, MD, Presenters
Credit: 1 AMA PRA Category 1 CreditsTM (CME) for Physicians
Fee: ASNC Members, free; Non-members, $75
This activity is supported by an educational grant from Pfizer.

Contemporary Diagnosis and Risk Assessment in Transthyretin Cardiomyopathy‚Äč 
Aired: February 2019
Faculty: Sharmila Dorbala, MD, MPH, FASNC, Chair, and Ronald M. Witteles, MD, Co-moderators. Mazen Hanna, MD and Martha Grogan, MD, Presenters
Credit: 1 AMA PRA Category 1 Credits™ (CME) for Physicians
Fee: ASNC Members, free; Non-members, $75
This activity is supported by an educational grant from Pfizer.

Online Activities

ASNC Cardiac Amyloidosis: Practice Essentials for Diagnosis and Management
Learn recent advances you can put into practice to improve outcomes for your patients with ATTR-CM.
Prem Soman, MD, PhD, MASNC (Chair)
Sharmila Dorbala, MD, MPH, FASNC
Mathew S. Maurer, MD
Frederick Ruberg, MD
Credit: 0.5 AMA PRA Category 1 Credits™.  Expiration Date: June, 13, 2020.
The activity is supported by an educational grant from Pfizer. ‚Äč

New! Cardiac Amyloidosis: Tc-99m PYP Imaging - How to Do It Right 
Robert Pagnanelli, BSRT(R)(N), CNMT, NCT, FASNC, Duke Regional Hospital, Durham, NC
April Mann, MBA, CNMT, NCT, RT(N), FANC, MASNC, Hartford Hospital, Hartford, CT 
This activity is supported by an educational grant from Pfizer. No CME/CE provided.


Practice Points 

Journal of Nuclear Cardiology 

ASNC Blog Posts

Other Articles

  • New drugs for cardiac amyloidosis provide hope for patients- UT Southwestern Medical Center- July 2019
  • Carpal Tunnel Syndrome: 'Red Flag' for Subsequent ATTR, Heart Failure- MedPage Today- July 2019
  • Potentially fatal buildup of proteins in the heart often goes undiagnosed AHA- May 2019
  • Natural History, Quality of Life, and Outcome in Cardiac Transthyretin Amyloidosis, AHA Journal Circulation- May 2019
  • Alexander KM, Singh A, Falk RH. Novel pharmacotherapies for cardiac amyloidosis. Pharmacol Ther. 2017;180:129-138.
  • Bokhari S, Morgenstern R, Weinberg R, Kinkhabwala M, Panagiotou D, Castano A, DeLuca A, Kontak A, Jin Z, Maurer MS. Standardization of 99mTechnetium pyrophosphate imaging methodology to diagnose TTR cardiac amyloidosis. J Nucl Cardiol. 2018;25:181–190. 
  • Castano A, Haq M, Narotsky DL, et al. Multicenter study of planar technetium 99m pyrophosphate cardiac imaging. Predicting survival for patients with ATTR cardiac amyloidosis. JAMA Cardiol. 2016;1:880-889.
  • Donnelly JP, Hanna M. Cardiac amyloidosis: An update on diagnosis and treatment. Cleve Clin J Med. 2017 Dec;84(12 Suppl 3):12-26.
  • Falk RH. Cardiac Amyloidosis: A treatable disease, often overlooked. Circulation 2011;124:1079–1085. 
  • Gillmore JD, Maurer MS, Falk RH, Merlini G, Damy T, Dispenzieri A, Wechalekar AD, Berk JL, Quarta CC, Grogan M, Lachmann HJ, Bokhari S, Castano A, Dorbala S, Johnson GB, Glaudemans AWJM, Rezk T, Fontana M, Palladini G, Miliani P, Guidalotti PL, Flatman K, Lane T, Vonberg FW, Whelan CJ, Moon JC, Ruberg FL, Miller EJ, Hutt DF, Hazenberg BP, Rapezzi C, Hawkins PN. Nonbiopsy diagnosis of cardiac transthyretin amyloidosis. Circulation 2016;133(24):2404-2412. 
  • Maurer MS, Elliott P, Comenzo R, Semigran M, Rapezzi C. Addressing common questions encountered in the diagnosis and management of cardiac amyloidosis. Circulation 2017;135:1357-1377. 
  • Maurer MS, Schwartz JH, Gundapaneni B, Elliott PM, Merlini G, Waddington-Cruz M, Kristen AV, Grogan M, Witteles R, Day T, Drachman BM, Shah SJ. Tafamidis treatment for patients with transthyretin amyloid cardiomyopathy. N Eng J Med. 2018; 379:1007-1016. 
  • Ruberg FL and Berk JL. Transthyretin (TTR) cardiac amyloidosis. Circulation 2012;126:1286-1300. 
  • Ruberg FL, Maurer MS, Judge DP, Zeldenrust S, Skinner M, Kim AY, Falk RH, Cheung KN, Patel AR, Pano A, Packman J, Grogan DR. Prospective evaluation of the morbidity and mortality of wild-type and V122I mutant transthyretin amyloid cardiomyopathy: The Transthyretin Amyloidosis Cardiac Study (TRACS). Am Heart J. 2012;164:222-228. 
  • Siddiqi OK, Ruberg FL. Cardiac amyloidosis: An update on pathophysiology, diagnosis, and treatment. Trends Cardiovasc Med. 2018;28:10-21. 
  • Vranian MN, Sperry BW, Valent J, Hanna M. Emerging advances in the management of cardiac amyloidosis. Curr Cardiol Rep. 2015;17:100. 
  • White JA and Fine NM. Recent advances in cardiovascular imaging relevant to the management of patients with suspected cardiac amyloidosis. Curr Cardiol Rep. 2016;18:77.

Partner Resources

Amyloidosis Foundation