Cardiac Amyloidosis

Cardiac Amyloidosis
ASNC is the premier source for education and quality in the rapidly expanding area of cardiac amyloidosis. Through its initiatives and partnerships, ASNC is supporting a collaborative approach to awareness, early diagnosis and effective treatments that will save lives and improve quality of life for patients with CA. As the medical society focused on nuclear cardiology, ASNC is uniquely qualified to provide education, information and advocacy that ensures appropriate referrals for Tc-99m PYP imaging; supports high-quality testing, interpretation and reporting of Tc-99m PYP imaging by imagers; and encourages fair reimbursement of Tc-99m PYP services and approval of CA treatment agents.


Register for these expert-led, case-based programs coming to a city near you!

Upcoming Webinar

Cases in Tc99m-PYP Evaluation of ATTR Cardiac Amyloidosis: Interpretation and Reporting

Date: Friday, April 3, 2020 Postponed and will be rescheduled
Time:  12:00 PM - 1:00 PM (US  Eastern Daylight Time)

This webinar will provide an overview of best practices and specific cases associated with the interpretation and reporting of Tc99m-PYP Evaluation of ATTR Cardiac Amyloidosis. This program will feature Drs. Jamieson Bourque, Edward Miller, Brett Sperry and Saurabh Malhotra. CME Credit will be available.


Jamieson M. Bourque, MD, MHS, FASNC Moderator
Associate Professor of Medicine and Radiology
Medical Director of Nuclear Cardiology and the Stress Laboratory
Medical Director of Culpeper Cardiology
University of Virginia Health System
Charlottesville, VA 

Edward J Miller, MD, PhD, FASNC - Presenter
Associate Professor of Medicine and Radiology in the Section of Cardiovascular Medicine
Director, Nuclear Cardiology, Cardiovascular Medicine
Director, Cardiology Fellowship Program, Cardiovascular Medicine
Yale School of Medicine
New Haven, CT 

Saurabh Malhotra, MD, MPH, FASNC – Presenter
Director of Advanced Cardiac Imaging Cook County Health
Associate Professor of Medicine Rush Medical College
John H. Stroger Hospital of Cook County
Chicago, IL 

Brett W Sperry, MD – Presenter
Cardiology, Advanced Heart Failure/Transplant Cardiology
Assistant Professor of Medicine, University of Missouri–Kansas City
Co-director of the Cardiac Amyloidosis Program
Saint Luke’s Mid America Heart Institute
Kansas City, MO 

Acknowledgement of Commercial Support
This activity is supported by an educational grant from Pfizer.

Archived Webinars

Complete archives are available at the ASNC Learning Center.

ASNC-IAEA  Archived Webinar

Advances in Cardiac Amyloidosis (ASNC-IAEA)
Moderators: Dr. Diana Paez and Dr. Prem Soman

  • Diagnosis of Cardiac Amyloidosis: ASNC/Multisocietal Consensus Recommendations: Sharmila Dorbala, MD, FASNC
  • 99mTc-Bone Tracer Imaging for ATTR Cardiac Amyloidosis: Professor, dr. Riemer Slart, MD, PhD
  • Novel Treatments for ATTR Cardiac Amyloidosis: Professer Claudio Rapezzi, MD
  • Discussion: Dr. Prem Soman

Sharmila Dorbala, MD, MPH, FASNC, Prem Soman, MD, PhD, MASNC, Diana Paez, MD, Professor Claudio Rapezzi, MD, Professor,dr. R.H.J.A. (Riemer) Slart
No CME or CE credit is provided.

Whom to Evaluate for Cardiac Amyloidosis: ASNC/Multisocietal Expert Consensus Recommendations
Faculty: Sharmila Dorbala, MD, MPH, FASNC, Moderator, Jamieson M. Bourque, MD, MHS, Brett W. Sperry, MD, Mathew S. Maurer, MD and Rodney H. Falk, MD, Presenters
CME/CE credit is not available for this activity
Fee: Complimentary
This activity is sponsored by Pfizer.

Clinical Application of Tc-99m PYP Imaging in Suspected Cardiac Amyloidosis
Faculty: Jamieson M. Bourque, MD, MHS and Sabahat Bokhari, MD, Presenters
CME/CE credit is not available for this activity
Fee: ASNC Members, free; Non-members, $25
This activity is sponsored by Pfizer.
Click here to access archive on ASNC Learning Center

Title: How to process Tc-99m PYP images for ATTR-CM: A hands-on presentation
Sabahat Bokhari, MD,  Director of Nuclear Cardiology
Columbia University Irving Medical Center
New  York Presbyterian Hospital
New York, New York

Lecture presented at the 2019 Annual Scientific Session of ASNC. No CME/CE provided.  If you have any questions, send them to This activity is supported by a grant from Pfizer.

Online Activities

ASNC Cardiac Amyloidosis: Practice Essentials for Diagnosis and Management
Learn recent advances you can put into practice to improve outcomes for your patients with ATTR-CM.
Faculty: Prem Soman, MD, PhD, MASNC (Chair), Sharmila Dorbala, MD, MPH, FASNC, Mathew S. Maurer, MD, Frederick Ruberg, MD
Credit: 0.5 AMA PRA Category 1 Credits™.  Expiration Date: June, 13, 2020.
The activity is supported by an educational grant from Pfizer. ‚Äč

Cardiac Amyloidosis: Tc-99m PYP Imaging - How to Do It Right 
Robert Pagnanelli, BSRT(R)(N), CNMT, NCT, FASNC, Duke Regional Hospital, Durham, NC
April Mann, MBA, CNMT, NCT, RT(N), FANC, MASNC, Hartford Hospital, Hartford, CT 
This activity is supported by an educational grant from Pfizer. No CME/CE provided.


Practice Points 

Journal of Nuclear Cardiology (JNC) 

ASNC Blog Posts


  • New drugs for cardiac amyloidosis provide hope for patients- UT Southwestern Medical Center- July 2019
  • Carpal Tunnel Syndrome: 'Red Flag' for Subsequent ATTR, Heart Failure- MedPage Today- July 2019
  • Potentially fatal buildup of proteins in the heart often goes undiagnosed AHA- May 2019
  • Natural History, Quality of Life, and Outcome in Cardiac Transthyretin Amyloidosis, AHA Journal Circulation- May 2019
  • Alexander KM, Singh A, Falk RH. Novel pharmacotherapies for cardiac amyloidosis. Pharmacol Ther. 2017;180:129-138.
  • Bokhari S, Morgenstern R, Weinberg R, Kinkhabwala M, Panagiotou D, Castano A, DeLuca A, Kontak A, Jin Z, Maurer MS. Standardization of 99mTechnetium pyrophosphate imaging methodology to diagnose TTR cardiac amyloidosis. J Nucl Cardiol. 2018;25:181–190. 
  • Castano A, Haq M, Narotsky DL, et al. Multicenter study of planar technetium 99m pyrophosphate cardiac imaging. Predicting survival for patients with ATTR cardiac amyloidosis. JAMA Cardiol. 2016;1:880-889.
  • Donnelly JP, Hanna M. Cardiac amyloidosis: An update on diagnosis and treatment. Cleve Clin J Med. 2017 Dec;84(12 Suppl 3):12-26.
  • Falk RH. Cardiac Amyloidosis: A treatable disease, often overlooked. Circulation 2011;124:1079–1085. 
  • Gillmore JD, Maurer MS, Falk RH, Merlini G, Damy T, Dispenzieri A, Wechalekar AD, Berk JL, Quarta CC, Grogan M, Lachmann HJ, Bokhari S, Castano A, Dorbala S, Johnson GB, Glaudemans AWJM, Rezk T, Fontana M, Palladini G, Miliani P, Guidalotti PL, Flatman K, Lane T, Vonberg FW, Whelan CJ, Moon JC, Ruberg FL, Miller EJ, Hutt DF, Hazenberg BP, Rapezzi C, Hawkins PN. Nonbiopsy diagnosis of cardiac transthyretin amyloidosis. Circulation 2016;133(24):2404-2412. 
  • Maurer MS, Elliott P, Comenzo R, Semigran M, Rapezzi C. Addressing common questions encountered in the diagnosis and management of cardiac amyloidosis. Circulation 2017;135:1357-1377. 
  • Maurer MS, Schwartz JH, Gundapaneni B, Elliott PM, Merlini G, Waddington-Cruz M, Kristen AV, Grogan M, Witteles R, Day T, Drachman BM, Shah SJ. Tafamidis treatment for patients with transthyretin amyloid cardiomyopathy. N Eng J Med. 2018; 379:1007-1016. 
  • Ruberg FL and Berk JL. Transthyretin (TTR) cardiac amyloidosis. Circulation 2012;126:1286-1300. 
  • Ruberg FL, Maurer MS, Judge DP, Zeldenrust S, Skinner M, Kim AY, Falk RH, Cheung KN, Patel AR, Pano A, Packman J, Grogan DR. Prospective evaluation of the morbidity and mortality of wild-type and V122I mutant transthyretin amyloid cardiomyopathy: The Transthyretin Amyloidosis Cardiac Study (TRACS). Am Heart J. 2012;164:222-228. 
  • Siddiqi OK, Ruberg FL. Cardiac amyloidosis: An update on pathophysiology, diagnosis, and treatment. Trends Cardiovasc Med. 2018;28:10-21. 
  • Vranian MN, Sperry BW, Valent J, Hanna M. Emerging advances in the management of cardiac amyloidosis. Curr Cardiol Rep. 2015;17:100. 
  • White JA and Fine NM. Recent advances in cardiovascular imaging relevant to the management of patients with suspected cardiac amyloidosis. Curr Cardiol Rep. 2016;18:77.

Partner Resources

Amyloidosis Foundation

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